ME/CFS Call 2026 - Consolidation

This is an invite-only call for research projects that address fundamental research questions to advance understanding of post-acute infectious diseases such as ME/CFS. The aim of this call is to support collaborative consortia who develop innovative research projects based on preliminary data generated in the first round of WWTF funding.

Call Facts

This is an invite-only call for proposals that address fundamental research questions to advance understanding of post-acute infectious diseases such as ME/CFS. The aim of this call is to support collaborative consortia who develop innovative research projects based on preliminary data generated in the first round of WWTF funding.


Scope of the Call            
This call invites collaborative consortia to advance critical knowledge in post-acute infectious diseases, with particular emphasis on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), through innovative projects that push the boundaries of current understanding in etiopathogenesis, diagnostics, and therapeutic interventions. We seek novel research approaches that address unexplored questions in the field, building strategically upon preliminary findings from the first round of WWTF funding, while integrating experimental and clinical methodologies through interdisciplinary teams. Successful proposals must demonstrate meaningful partnerships between researchers, patient representatives, and other relevant stakeholders. Interdisciplinary collaborations that leverage diverse scientific expertise to address complex research challenges are particularly encouraged. While ME/CFS represents a primary focus area, this call recognizes the broader landscape of post-acute infectious diseases, welcoming projects that investigate other conditions within this complex disease cluster that feature post-exertional malaise as a key symptom, with the ultimate goal of accelerating breakthrough discoveries that will improve patient outcomes and advance scientific understanding of these challenging conditions.

Who can apply?
Project Duration
24 – 36 months

Funding
             
Timeline            
Process

Call Specifications

Call Specifications

About

This document specifies the process, criteria, and instrument of this call. It is aimed at applicants wishing to submit a proposal in the ME/CFS Call 2026 - Consolidator Call. For further information regarding the funding and submission guidelines, as well as references to WWTF policies, please consider the following documents:

Submission Guideline Guide to creating, editing and submitting a proposal
WWTF Funding Guideline General Guideline for WWTF funding activities
Guideline for Good Scientific
Practice
Guidelines by the Austrian Agency for Research
Integrity
Open Science Policy Open Science Policy of WWTF
Gender Equality Strategy & Plan Gender Equality Strategy & Plan of WWTF
Accounting Guideline Specifies accounting for funded projects (german language only)
Call Specifications

Scope of the call

This call is issued within the WWTF instrument "project calls" (“Projekte”) specified in the WWTF Funding Guideline 

This call invites collaborative consortia to advance critical knowledge in post-acute infectious diseases, with particular emphasis on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), through innovative projects that push the boundaries of current understanding in etiopathogenesis, diagnostics, and therapeutic interventions. We seek novel research approaches that address unexplored questions in the field, building strategically upon preliminary findings from the first round of WWTF funding, while integrating experimental and clinical methodologies through interdisciplinary teams. Successful proposals must demonstrate meaningful partnerships between researchers, patient representatives, and relevant stakeholders, with particular encouragement for interdisciplinary collaborations that leverage diverse scientific expertise to tackle complex research challenges. While ME/CFS represents a primary focus area, this call recognizes the broader landscape of post-acute infectious diseases, welcoming projects that investigate other conditions within this complex disease cluster that feature post-exertional malaise as a key symptom, with the ultimate goal of accelerating breakthrough discoveries that will improve patient outcomes and advance scientific understanding of these challenging conditions.

Why ME/CFS?

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is a complex and poorly understood chronic disease. As part of the family of post-acute infectious diseases, it is characterised by a wide range of complex and serious, debilitating conditions with a variety of symptoms. This includes the cardinal symptom post-exertional malaise. Other symptoms like sleep dysfunction, pain, neurological/cognitive manifestations, as well as autonomic, immunological, and neuro-endocrinological symptoms are part of ME/CFS. Individuals with ME/CFS often do not return to pre-disease levels of activity. The cause of ME/CFS is currently unknown. ME/CFS affects individuals of all ages, ethnicities, and socioeconomic groups. It is estimated that in Austria up to 80.000 patients suffer from ME/CFS, with women being more likely to be diagnosed than men.

The goal of this call is to support larger consortia building upon promising preliminary findings that address fundamental research questions to advance understanding of post-acute infectious diseases such as ME/CFS. Highly welcome are:

The focus is on advancing the understanding of post-acute infectious diseases such as ME/CFS. However, projects investigating other post-acute infectious diseases that show substantial post-exertional malaise in their phenotype are also eligible for funding. Please note that solely observational projects in clinical settings and health service research do not fit the scope of this call.

Phenotypic Characteristics

ME/CFS: The definition of ME/CFS must be based on either of these international consensus criteria

Post-acute infectious diseases (PAIS): Other post-acute infectious diseases can also be investigated as part of the proposed research projects. Recent research has shown significant overlap in the biological mechanisms between a wide range of post-acute infectious diseases. Projects investigating other post-acute infectious diseases are therefore also invited (e.g., Long COVID). To be included in the scope of this call, the disease to be studied must meet the phenotypic criteria of post-exertional malaise as defined by one of the above-mentioned international consensus criteria.

Preliminary data and continuity

In this call, it is important to demonstrate continuity in your research approaches. Proposals must demonstrate continuity with previously funded exploratory WWTF ME/CFS projects based on generated preliminary data. Research questions and work plans should be developed along these lines, offering new perspectives and avenues of research, and/or crossing fields. It is important to present the status quo (whether positive or negative results have been achieved) and provide strong arguments to further develop the intended research.

Partnerships between researchers, patient representatives and relevant stakeholders

Proposals must demonstrate a clear strategy for structured, long-term engagement of carefully selected stakeholders throughout the research process, including patients (if possible), patient representatives, and other relevant non-academic partners. Consortia should show how they will implement formal structures and formats for stakeholder involvement—for example, through project governance roles like advisory boards, co-design of research processes and/or research priorities through regular consultation.

We particularly encourage innovative approaches to building partnerships with societal stakeholders that go beyond traditional engagement methods (e.g. science communication, online dashboards) and create genuine collaborative relationships by granting non-academic partners ownership of selected project outcomes.

Interdisciplinary Collaboration

In this call we encourage the collaboration between biomedical, computer and clinical sciences and other disciplines. The interdisciplinary expertise required for the proposed research project may be based within the same research group that received funding in the first round or traverse research groups and institutions. WWTF highly encourages the collaboration beyond already exisiting working groups. Plans for collaboration between expertise groups must be demonstrated throughout all critical stages of the project, from formulation of the research question, experimental design to data analyses.

Call Specifications

Financing of this call

This call is co-financed by the WE&ME Foundation and WWTF in equal shares. The WE&ME Foundation (formerly TEMPI Foundation) was established in 2020 by the Ströck family and is situated in Vienna, Austria, where the family is renowned for their "Ströck" bakeries, which have delighted generations with their baked goods. The Ströck family and the dedicated WE&ME team are committed to funding groundbreaking research that unveils the complexities of ME/CFS, moving closer to effective treatments and a cure.

Call Specifications

Submission

For the submission of the proposal written in English, please go to the WWTF Funding Portal.

Important Information for your Submission

Proposal deadline: June 23rd, 2026, 2 pm CET

Call Specifications

Consortia Building

Build interdisciplinary consortia that combine complementary expertise to create competitive, collaborative research teams.

Vienna's ME/CFS research community is smaller than other medical research communities, but this creates unique opportunities for collaboration and form synergies between groups to form a critical mass.

The previous WWTF ME/CFS 2024 - Understanding ME/CFS call successfully funded seven projects by combining established researchers with newcomers to the field - demonstrating first synergies across different fields. WWTF welcomes cosortia who build upon these synergies, if possible.

For this call, we strongly encourage:

Call Specifications

Eligibility of applicants and roles in the project

This is an invite-only call, meaning each WWTF-funded ME/CFS 2024 Understanding ME/CFS project is eligible to submit one proposal. This can be done by one of the Principal Investigators.

The general eligibility of applicants is specified in the WWTF Funding GuidelineA project’s core team may include up to three Principal Investigators (PIs). This includes a PI&C and up to two co-PIs.

One PI must be designated as PI&C.

Up to two co-PIs may also be named in the core team.

Additional project partners and collaborators are permitted in the research team.

Research partners outside Vienna: Project partners outside of Vienna may receive up to 30% of the total requested funding.

Call Specifications

Content and Structure of the Proposal

The application has to be submitted via https://fundingportal.wwtf.at. A user account (and registration) is required. You can also log-in with your ACOnet credentials.

Proposals must be written in English.

Structure of the proposal

The online form consists of five chapters and describes the entirety of the proposal:

Basic information 

This chapter contains basic information about the proposal, including title, scientific disciplines involved, keywords, and duration, and type of project (i.e., regular WWTF Project or Joint Project). Fill out fields as required.

Scientific Disciplines: Fields will be suggested as you type. WWTF uses the ÖFOS classification system of Statistik Austria. Take those disciplines most similar to your proposed project. WWTF will use this data only for statistical purposes. It is not relevant for the evaluation of your proposal. 

Personnel and Institutions

This chapter contains information about the main parties in the project. Please note that the terminology used in the Funding Portal stems from scientific research projects. In the context of this call, they have to be understood as analogies. 

To include 2 or 3 PIs or additional partner institutions in the project is not mandatory, but optional.

For each PI, an individual CV has to be uploaded in the "Profile". Please note, that the CV template has been made for scientific staff. Please feel free to adopt the CV template for technical staff. 

Project

This chapter contains the work programme. Fill out the following fields (please note that the character limit includes spaces):

Lay summary in German language: Please provide a description of your proposed research that is suitable for the general public. This will primarily be used by WWTF for communicating your work to non-experts for fundraising and public relations purposes. (1,000 characters)

Abstract for experts: Please provide a concise project description. (2,000 characters)

Work programme: Please use the template provided for download in the WWTF Funding Portal. The headings in bold are mandatory. 

Chapters of the work programme (PDF upload, max 15 pages incl. references):

1. Introduction, state-of-the-art and preliminary data

What exactly is the research subject, and why does it matter now for the ME/CFS or PAIS field? What are the critical unresolved challenges in the field, and how do your specific preliminary findings from the first WWTF project create a foundation that uniquely positions your consortium to address them?

2. Hypotheses and objectives

Are your hypotheses specific, testable, and clearly derived from your preliminary data? Do your objectives map logically onto the hypotheses, and are they achievable within 24–36 months?

3. Innovativeness and relevance

What is genuinely new here, in concept, methodology, or combination, compared to what the field is already doing? How will results concretely advance the PAIS/ME/CFS field, and will patient perspectives shape the research design rather than being added as an afterthought?

4. Research plan and methods

Is your cohort sufficiently powered, is recruitment realistic within the timeline, and how are sex and gender dimensions explicitly integrated into design and analysis? Does each milestone have a clear deliverable, and does the team demonstrably hold the methodological expertise required for every analytical approach proposed?

5. Consortia building and governance structure 

Who are your stakeholders beyond the research team, and what concrete mechanisms ensure their sustained, meaningful involvement? How are decisions made and resources allocated within the project consortia?

6. Interdisciplinarity, project management and feasibility

What does each discipline contribute that the others cannot, and where exactly do they intersect in the research plan? What are the two or three biggest risks to project completion, what are your mitigation strategies, and how is data managed, shared, and prepared for dissemination from day one?

7. Key references 

No prescription regarding number of references.

Use the word template in the Funding Portal for filling out the application. 

Applicants can decide how much space they want to spend in each subheading.

Upload the completed document as PDF. The number of pages is limited to max. 15. 

Ethical Considerations: Please describe potential ethical aspects of your project (or why they contain none) and explain how you deal with them. 

Gender Aspects: Please provide considerations on gender aspects in the project. More details can be found here .

Budget

The budget table to be filled out is divided in personnel and non-personnel cost.

Please consider WWTF rules for eligible costs

A text box is provided to explain costs. 

Signatures

Submission of the proposal requires the signatures of the authorized person(s) at the host institutions of each of the PI&C and co-PIs (“Authorization”).

Please ensure signatures are dated. Undated signatures will not be accepted.

Unlike proposals in the previous WWTF Legacy Submission System, signatures from the core team are no longer required in the new Funding Portal.

Call Specifications

Eligible costs

All costs that are directly attributable to the project and are regarded as commonly required in the respective scientific fields are eligible for funding. Please also consider your organization’s internal guidelines for eligible expenses/costs.

Details: Anerkennung von Kosten bei WWTF Förderungen 

Personnel costs

WWTF is dedicated to funding researchers. Hence, the larger share of the project’s budget should be allocated to personnel costs for researchers working on the project.

Non-personnel costs

Running costs for basic infrastructure (telephone costs, rents) as well as costs for the acquisition of infrastructure and basic equipment are not eligible for funding, as these should be covered by the category “overhead costs”. The following categories of non-personnel costs are eligible for funding:

Non-personnel costs should not exceed 40% of the overall budget.

Indirect costs (overheads)

 WWTF pays a maximum of 20% overhead.

Overhead is calculated as a percentage of the direct costs of the project (i.e., personnel + non-personnel costs). Please note that WWTF offers the maximum 20% overhead lump sum to compensate for all administration costs. This means that flat fees for payroll or project accounting are not eligible. The total funding volume is calculated as direct plus indirect costs.

Applicants are required to comply with the overhead regulations of the involved institutions.

Call Specifications

Funding and evaluation criteria

The following criteria are used in the evaluation.

The key criteria in the evaluation of proposals are scientific quality, novelty, interdisciplinarity and transdisciplinarity:

Further criteria include academic & clinical impact, feasibility of the proposed project plan, Data management and Gender aspects. Please note that career breaks such as for parental leave, care duty and prolonged illness will be taken into account in the evaluation of the proposals. In order for these to be considered, please provide the relevant time periods.

Call Specifications

Selection and decision process

The core element of WWTF’s decision-making processes is an international jury mandated to make a funding recommendation to the WWTF boards.

Formal eligibility check by WWTF

WWTF office conducts a formal eligibility check of the proposal based on the criteria outlined in the WWTF Funding Guideline. Substantial deficiencies and missing sections in the application will lead to the exclusion of the application from further evaluation and rejection on formal grounds. The strict timeline of the call does not allow for proposals to be sent back to the applicants for amendments.

Evaluation of proposals

Eligible full proposals will undergo a review process

Formal funding decision

The jury recommendation will be formally confirmed first by the WWTF Advisory Board and then approved by the WWTF Board of Directors.

Call Specifications

Gender aspects in the application phase

WWTF’s Gender Strategy and Gender Equality Plan must be considered throughout the application. Please note that WWTF requests jury members and reviewers to take into account both gender and specific roles in research team composition, as well as gender in research content during evaluation processes.

The following questions should be considered during development of the proposal:

Equal opportunities in research

Gender in research content and in the research ideas phase

Proposal phase

Research phase


Further resources

Call Specifications

Guidelines for good scientific practice and ethics

Compliance with the rules for good scientific practice, including the observance of ethical aspects in research, is mandatory. This pertains to the application process and, in case of funding, the actual research work. WWTF is member of the OeAWI and processes apply accordingly.

Project proposals may include ethical aspects that require the approval from an ethics committee/institutional review board.

Call Specifications

Open Science

WWTF requires compliance with its Open Science Policy. This document outlines the rights, roles and responsibilities of WWTF, researchers, and research organizations.

Call Specifications

Use of generative AI in the application process

WWTF recognizes that the use of genAI tools is pervasive and can facilitate proposal writing, for example in relation to improving written language. However, substantial use of genAI must be declared as such for the sake of transparency. 

“Substantial use” is defined in line with the European Commission’s definition: “[…] using generative AI as a basic author support tool is not a substantial use. However, interpreting data analysis, carrying out a literature review, identifying research gaps, formulating research aims, developing hypotheses, etc. could have a substantial impact.” (EC 2025: Living Guidelines on the responsible use of generative AI in research. Second Version, April 2025)  

This mainly concerns critical parts of scientific relevance, such as hypothesis formulation and the scientific project plan. Applicants will be required to provide statements on the use of generative AIs at both the short and full proposal stages. WWTF emphasizes the importance of human responsibility for the content submitted at all stages of the application process. 

WWTF does not allow the use of genAI in the evaluation process.

Call Specifications

Funding contract

In case of funding, WWTF office will contact the PI&C to draw up the funding contract. 

Projects should start the latest in Q1 / 2027

Call Specifications

Public relations and Community activities

Funded projects will be showcased via WWTF and WE&ME public relations activities. This includes displaying the projects via respective websites, contributing to other multimedia activities or presenting the work at stakeholder meetings relevant for making the outcomes of this call visible. To strengthen the ME/CFS research community, funded projects will also be invited to particpate in community actitivies.

Call Specifications

Monitoring and reporting

Funded teams commit themselves to delivering reports and participating in evaluation and monitoring. WWTF offers the possibility to adapt the work plan according to project needs. 

Details here

Submission Guideline

Submission Guideline

General Manual of the Funding Portal

For the manual regarding the general features (create account, login, etc.) of the Funding Portal see here.

Submission Guideline

Create a Proposal

This is an invite-only call. It features a pre-selection process by your team in order to decide who will be the eligible applicant for each of the 7 project teams for this consolidation call. Once this decision has been made, the team needs to inform WWTF of the eligible PI and provide their email address, to which WWTF will create a proposal within the Funding Portal.

Upon login, you will find your proposal ready to be filled out. 

To be able to access your proposal, you either need an WWTF account or login with your institutional address (for ACOnet participants). 

Submission Guideline

Create Roles (PI / Co-PIs) for a Proposal

WWTF requires information only about the researchers in the project’s core team, i.e., the PI&C and up to two co-PIs.

How to invite PIs & Co-PIs to the proposal:

Step 1: Invite the PI&C and co-PIs

  1. Go to the tab “Personnel and Institutions” in the proposal
  2. Invite a “Principal Investigator and Coordinator” by providing their contact information.

Step 2: Complete your “Profile”

The PI&C and all co-PIs must complete “My Profile”If you are creating a project on behalf of others and are not part of the Core Team, you do not need to provide this information.

  1. Upon login, go to “My Profile” in the top menu to fill out or update your profile. This information needs to be entered only once and can then be used for multiple proposals or in future calls.

Step 3: Complete your “Role”

Go to “My Proposal & Roles” in the top menu. Under “My Roles”, click on your role below the title of the proposal.

Please note that the term "Scientific Expertise" means "Expertise" in this call. WWTF cannot change the heading without affecting other calls. 

Please note that the information entered here should be specific to the project. If you are participating in multiple proposals that requires different subsets of your expertise, please tailor the information according to the project.

As the Funding Portal automatically relays entered information about the PI&C and co-PIs into subsequent parts of the proposal, we recommend that the core team members fill out these sections early (e.g., institutions of the core team members are automatically added to the budget).

Submission Guideline

Chapters to fill out

Regarding details, please see here.

Submission Guideline

CVs

Please use the CV template provided in the funding portal. Please use the following template:"All other calls: wwtf_cvtemplate_project.docx"

Do not exceed 2 pages for the CV, as the system will not accept the upload of documents longer than 2 pages

Different CVs in case of the submission of two proposals within a call

Applicants have the possibility to submit two proposals. This may necessitate slightly different versions of the CV (publications specific to the proposals). In this case, the following procedure is recommended:

Now, the CV is imported from your profile to Proposal A, and only to Proposal A! 

As a result, Proposal A and B should have different CVs. 

Submission Guideline

Submit your Proposal

Once all symbols in all chapters are marked by green checkmarks, the proposal can be submitted. The “Submit” button is at the bottom of the “Signatures” chapter. 

The PI&C will receive an automatic confirmation email when the Funding Portal receives the completed submission. Please check your emails after hitting the submit button. If you do not receive a confirmation email, please get in touch with the Call Manager. 

You can access your submitted proposal as PDF on the page “My Proposals and Roles”. 

No changes are possible after the project has been submitted. After the indicated deadline, submission is no longer possible. Unsubmitted proposals will be excluded from the ensuing evaluation process and deleted shortly after the submission deadline.

Contact

Missbach.jpg Liu.jpg

Benjamin Missbach | benjamin.missbach@wwtf.at | Tel.: +43 1 402 31 43 19

Grace Liu | grace.liu@wwtf.at | Tel.: +43 1 402 31 43 12